Article
Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease.
Journal of human genetics - 1 Jan 2005
Yang Yu, Lingling Sun, Ying Jin, Yushu Li, Zhongyan Shan, Wei Huang, Weiping Teng
Abstract excerpt
Graves' disease (GD) was believed to be a polygenic disease. Several chromosomal regions were linked to GD, and the 5q31 chromosome regions containing several interleukin genes cluster were worth observing. In this study, IL4, IL13, IRF1 and UGRP1 genes were sequenced, and 5, 3, 7 and 7 polymorphisms respectively were discovered. Then an extended association study for the attracting polymorphisms was performed...
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