Article
Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23.
Cell death and differentiation - 1 Mar 2006
Rao R V, Niazi K, Mollahan P, Mao X, Crippen D, Poksay K S, Chen S, Bredesen D E
Abstract excerpt
The endoplasmic reticulum (ER) is the principal organelle for the biosynthesis of proteins, steroids and many lipids, and is highly sensitive to alterations in its environment. Perturbation of Ca(2+) homeostasis, elevated secretory protein synthesis, deprivation of glucose or other sugars, altered glycosylation and/or the accumulation of misfolded proteins may all result in ER stress, and prolonged ER stress...
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