Article
Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation.
The Journal of biological chemistry - 7 Sept 2001
Rao R V, Hermel E, Castro-Obregon S, del Rio G, Ellerby L M, Ellerby H M, Bredesen D E
Abstract excerpt
The endoplasmic reticulum (ER) is the site of assembly of polypeptide chains destined for secretion or routing into various subcellular compartments. It also regulates cellular responses to stress and intracellular Ca(2+) levels. A variety of toxic insults can result in ER stress that ultimately leads to apoptosis. Apoptosis is initiated by the activation of members of the caspase family and serves as a central...
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