Article
Endocytosis plays a critical role in proteolytic processing of the Hendra virus fusion protein.
Journal of virology - 1 Oct 2005
Meulendyke Kelly Ann, Wurth Mark Allen, McCann Richard O, Dutch Rebecca Ellis
Abstract excerpt
The Hendra virus fusion (F) protein is synthesized as a precursor protein, F(0), which is proteolytically processed to the mature form, F(1) + F(2). Unlike the case for the majority of paramyxovirus F proteins, the processing event is furin independent, does not require the addition of exogenous proteases, is not affected by reductions in intracellular Ca(2+), and is strongly affected by conditions that raise the...
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