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VP2 mediates the release of the feline calicivirus RNA genome by puncturing the endosome membrane of infected cells

9 Apr 2024

Abstract excerpt

family that grows well in cell lines and, therefore, serves as a surrogate to study the biology of other viruses in the family. Conley et al. (14) demonstrated that upon the receptor engagement to the capsid, FCV VP2 forms a portal-like assembly, which might provide a channel for RNA release. However, the process of calicivirus RNA release is not yet fully understood. Our findings suggest that the separation of...

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PMID: 38591900
DOI: 10.1128/jvi.00350-24

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