Article
The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR.
The Journal of biological chemistry - 9 Dec 2005
Wennerhold Julia, Krug Andreas, Bott Michael
Abstract excerpt
The mRNA level of the aconitase gene acn of Corynebacterium glutamicum is reduced under iron limitation. Here we show that an AraC-type regulator, termed RipA for "regulator of iron proteins A," is involved in this type of regulation. A C. glutamicum DeltaripA mutant has a 2-fold higher aconitase activity than the wild type under iron limitation, but not under iron excess. Comparison of the mRNA profiles of the...
Topics
- Aconitate Hydratase
- AraC Transcription Factor
- Bacterial Proteins
- Binding Sites
- Catalase
- Corynebacterium glutamicum
- DNA
- DNA-Binding Proteins
- Escherichia coli
- Gene Expression Regulation
- Iron
- Mutation
- Nonheme Iron Proteins
- Operon
- Promoter Regions, Genetic
- RNA, Messenger
- Recombinant Proteins