An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration.

Abstract excerpt

There is mounting evidence for mitochondrial involvement in neurodegenerative diseases including Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis. Mitochondrial DNA mutations, whether inherited or acquired, lead to impaired electron transport chain (ETC) functioning. Impaired...

Topics

• Animals
• Cell Death
• Cell Nucleus
• Humans
• Mitochondria
• Mutation
• Neurodegenerative Diseases
• Oxidative Stress