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Defective ATM‐p53–mediated apoptotic pathway in multiple sclerosis

21 Sept 2005

Abstract excerpt

Defective elimination of autoreactive cells is thought to play a role in the development of autoimmune diseases including multiple sclerosis (MS). We examined the activation of the ATM-CHK2-p53 pathway in MS patients after subjecting their peripheral blood mononuclear cells to gamma-irradiation. We found that peripheral blood mononuclear cells from a subset of MS patients show resistance to cell death induced by...

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PMID: 16178012
DOI: 10.1002/ana.20600

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