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Article

Defective T cell Fas function in patients with multiple sclerosis

10 Oct 2000

Abstract excerpt

BACKGROUND: Fas (CD95) triggers programmed cell death and is involved in shutting off the immune response. Inherited deleterious mutations hitting Fas or its signaling pathway cause autoimmune/lymphoproliferative syndrome (ALPS). OBJECTIVE: To assess the possibility that decreased Fas function plays a role in development of MS. METHODS: The authors evaluated Fas function in long-term T cell lines (21 days of...

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Identifiers

PMID: 11061245
DOI: 10.1212/wnl.55.7.921

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