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Isocitrate Lyase Activity Is Required for Virulence of the Intracellular Pathogen Rhodococcus equi

21 Sept 2005

Abstract excerpt

Rhodococcus equi is an important pathogen of foals, causing severe pyogranulomatous pneumonia. Virulent R. equi strains grow within macrophages, a process which remains poorly characterized. A potential source of carbon for intramacrophage R. equi is membrane lipid-derived fatty acids, which following beta oxidation are assimilated via the glyoxylate bypass. To assess the importance of isocitrate lyase, the first...

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PMID: 16177351
DOI: 10.1128/iai.73.10.6736-6741.2005

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