The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.

doi:10.1371/journal.pgen.1001145

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Article

The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.

PLoS genetics - 30 Sept 2010

Letek Michal, González Patricia, Macarthur Iain, Rodríguez Héctor, Freeman Tom C, Valero-Rello Ana, Blanco Mónica, Buckley Tom, Cherevach Inna, Fahey Ruth, Hapeshi Alexia, Holdstock Jolyon, Leadon Desmond, Navas Jesús, Ocampo Alain, Quail Michael A, Sanders Mandy, Scortti Mariela M, Prescott John F, Fogarty Ursula, Meijer Wim G, Parkhill Julian, Bentley Stephen D, Vázquez-Boland José A

Abstract excerpt

We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of environmental rhodococci. This is due to genome expansion in nonpathogenic species, via a linear gain of paralogous genes and an accelerated genetic flux, rather...

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PMID: 20941392
DOI: 10.1371/journal.pgen.1001145
PMCID: PMC2947987

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