Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.

doi:10.1128/jb.176.19.6007-6014.1994

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Article

Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.

Journal of bacteriology - 1 Oct 1994

Wozniak D J, Ohman D E

Abstract excerpt

Strains of Pseudomonas aeruginosa which colonize and infect the lungs of cystic fibrosis patients have a mucoid colony morphology due to the overproduction of the exopolysaccharide alginate. The response regulators AlgB and AlgR are required for the transcription of algD, a tightly regulated gene encoding GDP-mannose dehydrogenase, which is critical for P. aeruginosa alginate biosynthesis. Previous studies...

Topics

Alginates
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Carbohydrate Dehydrogenases
DNA-Binding Proteins
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genes, Regulator
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenotype

Pseudomonas aeruginosa

Sigma Factor

Signal Transduction

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7928961
DOI: 10.1128/jb.176.19.6007-6014.1994
PMCID: PMC196818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7928961-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.PMID 7928961Read ↗

Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA-binding protein, is essential for alginate synthesis and algD transcriptional activation.Semantic proximity Read ↗

Identification and characterization of AlgZ, an AlgT-dependent DNA-binding protein required for Pseudomonas aeruginosa algD transcription.Semantic proximity Read ↗

The Transcriptional Regulator AlgR Is Essential for Pseudomonas aeruginosa PathogenesisSemantic proximity Read ↗

DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats.Semantic proximity Read ↗

Genetic analysis of the alginate biosynthetic gene cluster of <i>Pseudomonas aeruginosa</i> shows evidence of an operonic structureSemantic proximity Read ↗

Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation.Semantic proximity Read ↗

Pseudomonas aeruginosa AlgB, a two-component response regulator of the NtrC family, is required for algD transcriptionSemantic proximity Read ↗

The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E).Semantic proximity Read ↗

Role of an alginate lyase for alginate transport in mucoid Pseudomonas aeruginosa.Semantic proximity Read ↗

A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species.Semantic proximity Read ↗

Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion.Semantic proximity Read ↗

Pseudomonas aeruginosa AlgB, which modulates the expression of alginate, is a member of the NtrC subclass of prokaryotic regulators.Semantic proximity Read ↗

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