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Evidence for Selective Expression of the p53 Codon 72 Polymorphs: Implications in Cancer Development

1 Sept 2005

Abstract excerpt

Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Asians were found to preferentially...

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PMID: 16172238
DOI: 10.1158/1055-9965.epi-05-0153

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