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Article

Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling.

Biochemistry - 7 Aug 2012

Afriat-Jurnou Livnat, Jackson Colin J, Tawfik Dan S

Abstract excerpt

Only decades after the introduction of organophosphate pesticides, bacterial phosphotriesterases (PTEs) have evolved to catalyze their degradation with remarkable efficiency. Their closest known relatives, lactonases, with promiscuous phosphotriasterase activity, dubbed PTE-like lactonases (PLLs), share only 30% sequence identity and also differ in the configuration of their active-site loops. PTE was therefore...

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PMID: 22809311
DOI: 10.1021/bi300694t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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