Article
A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil.
The Journal of infectious diseases - 15 May 2010
Lázaro Fernando P, Werneck Renata I, Mackert Ciane C O, Cobat Aurélie, Prevedello Flávia C, Pimentel Raphaela P, Macedo Geraldo M M, Eleutério Marco A M, Vilar Guilherme, Abel Laurent, Xavier Marília B, Alcaïs Alexandre, Mira Marcelo T
Abstract excerpt
BACKGROUND: Leprosy is a chronic infectious disease that affects 250,000 new individuals/year worldwide. Genetic analysis has been successfully applied to the identification of host genetic factors affecting susceptibility to leprosy; however, a consensus regarding its mode of inheritance is yet to be achieved. METHODS: We conducted a complex segregation analysis (CSA) on leprosy using data from the Prata Colony,...
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