Article
The fingerprint of phantom mutations in mitochondrial DNA data.
American journal of human genetics - 1 Nov 2002
Bandelt Hans-Jürgen, Quintana-Murci Lluís, Salas Antonio, Macaulay Vincent
Abstract excerpt
Phantom mutations are systematic artifacts generated in the course of the sequencing process itself. In sequenced mitochondrial DNA (mtDNA), they generate a hotspot pattern quite different from that of natural mutations in the cell. To identify the telltale patterns of a particular phantom mutation process, one first filters out the well-established frequent mutations (inferred from various data sets with...
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