Article

Performance of a Non-Invasive Blood Test for a Conformational Variant of p53 to Predict Alzheimer’s Disease Within 6 Years of Clinical Diagnosis

2021-05-12

Abstract excerpt

<h4>Background: </h4> Research continues to search for blood-based biomarkers sensitive to Alzheimer’s disease (AD) pathology during the initial stages when symptoms of cognitive decline are not yet apparent. A blood-based biomarker candidate is metalloprotein p53, the conformation of which was previously found to be altered in peripheral cells from individuals with mild cognitive impairment (MCI) and AD, pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef84c120-d57e-53b2-ad50-70166e72d436
DOI: 10.20944/preprints202105.0267.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Performance of a Non-Invasive Blood Test for a Conformational Variant of p53 to Predict Alzheimer’s Disease Within 6 Years of Clinical DiagnosisDOI 10.20944/preprints202105.0267.v1Read

A conformational variant of p53 (U-p53<sup>AZ</sup>) as blood-based biomarker for the prediction of the onset of symptomatic Alzheimer’s diseaseSemantic proximity Read

A Conformational Variant of p53 (U-p53AZ) as Blood-Based Biomarker for the Prediction of the Onset of Symptomatic Alzheimer's DiseaseSemantic proximity Read

Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry PlatformsSemantic proximity Read

The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer’s diseaseSemantic proximity Read

Serum-based Protein Profiles of Alzheimer’s Disease and Mild Cognitive Impairment in Elderly HispanicsSemantic proximity Read

Predicting Preclinical Cognitive Decline Using Plasma P-tau217 and <i>APOE</i> Genotype in 8,582 Individuals From Different Ethnic GroupsSemantic proximity Read

Conformationally Altered p53: A Putative Peripheral Marker for Alzheimer’s DiseaseSemantic proximity Read

Discovery of plasma protein biomarkers related to Alzheimer’s disease, sex and APOE genotypeSemantic proximity Read

Amyloid blood biomarker detects Alzheimer's diseaseSemantic proximity Read

Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53.Semantic proximity Read

Pittsburgh plasma p-tau217: classification accuracies for autosomal dominant and sporadic Alzheimer’s disease in the communitySemantic proximity Read

Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.Semantic proximity Read