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Article

Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.

The Journal of infectious diseases - 15 Jan 2011

Alam Md Tauqeer, de Souza Dziedzom K, Vinayak Sumiti, Griffing Sean M, Poe Amanda C, Duah Nancy O, Ghansah Anita, Asamoa Kwame, Slutsker Laurence, Wilson Michael D, Barnwell John W, Udhayakumar Venkatachalam, Koram Kwadwo A

Abstract excerpt

BACKGROUND: In 2005, Ghana adopted artemisinin-based combination therapy (ACT) for primary treatment of falciparum malaria. A comprehensive study of the drug-resistance-associated mutations and their genetic lineages will lead to a better understanding of the evolution of antimalarial drug resistance in this region. METHODS: The pfcrt, pfmdr1, dhps, and dhfr mutations associated with chloroquine (CQ) and...

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Identifiers

PMID: 21288822
DOI: 10.1093/infdis/jiq038
PMCID: PMC3071065

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Source receipt: pubmed, retrieved 7 Sept 2026.

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