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Article

The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005

Kim Dong Wook, Lenzen Gerlinde, Page Anne-Laure, Legrain Pierre, Sansonetti Philippe J, Parsot Claude

Abstract excerpt

Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion system to inject effector proteins into host cells and induce their entry into epithelial cells or trigger apoptosis in macrophages. We present evidence that the effector OspG is a protein kinase that binds various ubiquitinylated ubiquitin-conjugating enzymes, including UbcH5, which belongs to the stem cell factor...

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Identifiers

PMID: 16162672
DOI: 10.1073/pnas.0504466102
PMCID: PMC1236552

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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