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Article

Transcriptional silencing of Polo-like kinase 2<i>(SNK/PLK2)</i>is a frequent event in B-cell malignancies

14 Sept 2005

Abstract excerpt

The Polo-like kinases (Plks) are a highly conserved family of protein kinases that function in regulation of cell cycle and DNA damage-induced checkpoints. Evidence of a tumor suppressor function for the Plks in human neoplasia is lacking. Here, we report that Snk/Plk2 is transcriptionally down-regulated in B-cell neoplasms. Silencing occurs with very high frequency in Burkitt lymphoma (BL) but is also detected...

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Identifiers

PMID: 16160013
DOI: 10.1182/blood-2005-03-1194

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