Article
Rare causes of hereditary iron overload.
Seminars in hematology - 1 Oct 2002
Ponka Prem
Abstract excerpt
Iron is a vitally important element in mammalian metabolism because of its unsurpassed versatility as a biologic catalyst. However, when not appropriately shielded or when present in excess, iron plays a key role in the formation of extremely toxic oxygen radicals, which ultimately cause peroxidative damage to vital cell structures. Organisms are equipped with specific proteins designed for iron acquisition,...
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