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Article

Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes.

The pharmacogenomics journal - 1 Jan 2005

Fiegenbaum M, Silveira F R, Van der Sand C R, Van der Sand L C, Ferreira M E W, Pires R C, Hutz M H

Abstract excerpt

We investigated the effect of single-nucleotide polymorphisms in sterol regulatory element-binding factors-1a and -2 (SREBF-1a and SREBF-2) and SREBF cleavage-activating protein (SCAP) genes on lipid-lowering response to simvastatin. In all, 146 hypercholesterolemic patients of European descent were prospectively treated with simvastatin 20 mg/day for over 6 months. Of these 99 subjects completed the 6-month...

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Identifiers

PMID: 16158080
DOI: 10.1038/sj.tpj.6500334

Genes

SCAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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