Article
Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.
The American journal of cardiology - 15 Mar 2006
Simon Joel A, Lin Feng, Hulley Stephen B, Blanche Patricia J, Waters David, Shiboski Stephen, Rotter Jerome I, Nickerson Deborah A, Yang Huiying, Saad Mohammed, Krauss Ronald M
Abstract excerpt
Although statins are effective lipid-lowering agents, the phenotypic and demographic predictors of such lowering have been less well examined. We enrolled 944 African-American and white men and women who completed an open-label, 6-week pharmacogenetics trial of 40 mg of simvastatin. The phenotypic and demographic variables were examined as predictors of the change in lipids and lipoproteins using linear...
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