A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.

doi:10.1016/j.jpsychires.2005.01.007

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Article

A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study.

Journal of psychiatric research - 1 Nov 2005

Praschak-Rieder Nicole, Willeit Matthäus, Zill Peter, Winkler Dietmar, Thierry Nikolaus, Konstantinidis Anastasios, Masellis Mario, Basile Vincenzo S, Bondy Brigitta, Ackenheil Manfred, Neumeister Alexander, Kaplan Allan S, Kennedy James L, Kasper Siegfried, Levitan Robert

Abstract excerpt

Most females with seasonal affective disorder (SAD) exhibit atypical vegetative symptoms such as overeating, and weight gain when depressed. The serotonin 2C receptor (5-HT(2C)) plays a key role in control of appetite and satiety. A 5-HT(2C) Cys 23 Ser substitution, coded for by a single nucleotide polymorphism (Cys 23 Ser) within the 5-HT(2C) gene, has been shown to influence 5-HT(2C) function. We hypothesized...

Topics

Adult
Appetite
Body Mass Index
Body Weight
Case-Control Studies
Female
Gene Dosage
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Receptor, Serotonin, 5-HT2C

Satiation

Seasonal Affective Disorder

Weight Gain

Source

Open in PubMed

Identifiers

PMID: 16157158
DOI: 10.1016/j.jpsychires.2005.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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