Article
Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2004
Levitan R D, Masellis M, Lam R W, Muglia P, Basile V S, Jain U, Kaplan A S, Tharmalingam S, Kennedy S H, Kennedy J L
Abstract excerpt
There is significant evidence that altered dopamine activity plays a role in seasonal affective disorder (SAD). The current study examined three separate genetic hypotheses for SAD related to the 7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), a variant associated with decreased affinity for dopamine. We examined the possible contribution of 7R to the overall expression of SAD, attention deficit...
Topics
- Adult
- Alleles
- Attention Deficit Disorder with Hyperactivity
- Body Mass Index
- Body Weight
- Case-Control Studies
- Chi-Square Distribution
- Factor Analysis, Statistical
- Female