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Article

The frequency of the sickle allele in Jamaica has not declined over the last 22 years

25 Aug 2005

Abstract excerpt

The 'malaria hypothesis' predicts that the frequency of the sickle allele, which is high in malaria-endemic African populations, should decline with each generation in populations of African descent living in areas where malaria is no longer endemic. In order to determine whether this has been the case in Jamaica, we compared haemoglobin electrophoresis results from two hospital-based screening programmes...

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PMID: 16156863
DOI: 10.1111/j.1365-2141.2005.05704.x

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