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Article

Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression.

Biomaterials - 1 Mar 2006

Hyun Jinho, Chen Jun, Setton Lori A, Chilkoti Ashutosh

Abstract excerpt

We describe the fabrication of deformable microstructures by low-pressure-soft-microembossing (muSEmb) that provides in vitro experimental "test-beds" to investigate the interplay of mechanical and chemical stimuli on cell behavior in a highly controlled environment. Soft microembossing exploits the softness and plasticity of parafilm to fabricate microstructures by pressing a silicon master or an elastomeric...

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Identifiers

PMID: 16154191
DOI: 10.1016/j.biomaterials.2005.08.018

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