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Article

Microcephalin guards against small brains, genetic instability, and cancer.

Cancer cell - 1 Aug 2006

Bartek Jiri

Abstract excerpt

Through its roles in cell cycle control and DNA damage response, microcephalin (also known as BRIT1 or MCPH1) has been implicated in fundamental biological processes, including regulation of brain size and maintenance of genomic integrity. Two new reports in Nature Cell Biology and this issue of Cancer Cell provide further insights into the functions of microcephalin in DNA damage checkpoints and timing of...

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Source

Identifiers

PMID: 16904606
DOI: 10.1016/j.ccr.2006.07.014

Genes

MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Microcephalin guards against small brains, genetic instability, and cancer.PMID 16904606Read ↗

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Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH)Semantic proximity Read ↗

Same but different: pleiotropy in centrosome-related microcephaly.Semantic proximity Read ↗

Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings.Semantic proximity Read ↗

CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly.Semantic proximity Read ↗

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