Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB.

Virology - 1 Sept 2007

Zhang Xue, Wu Kailang, Wang Di, Yue Xin, Song Degui, Zhu Ying, Wu Jianguo

Abstract excerpt

High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Artificial Gene Fusion
Share to Coronavirus Nucleocapsid Proteins
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Luciferases

Share to NF-kappa B

Share to Nucleocapsid Proteins

Share to Severe acute respiratory syndrome-related coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 17490702
DOI: 10.1016/j.virol.2007.04.009
PMCID: PMC7103332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17490702-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB.PMID 17490702Read ↗

Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein.Semantic proximity Read ↗

Activation of NF-kappaB by the full-length nucleocapsid protein of the SARS coronavirus.Semantic proximity Read ↗

The Role of SARS-CoV-2 Nucleocapsid Protein in Host InflammationSemantic proximity Read ↗

Adenovirus 7 Induces Interlukin-6 Expression in Human Airway Epithelial Cells via p38/NF-κB Signaling PathwaySemantic proximity Read ↗

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVSSemantic proximity Read ↗

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosisSemantic proximity Read ↗

Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response.Semantic proximity Read ↗

Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid proteinSemantic proximity Read ↗

SARS-CoV Accessory Protein 3b Induces AP-1 Transcriptional Activity through Activation of JNK and ERK PathwaysSemantic proximity Read ↗

Role of IL-6–IL-27 Complex in Host Antiviral Immune ResponseSemantic proximity Read ↗

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathwaySemantic proximity Read ↗

The structure analysis and antigenicity study of the N protein of SARS-CoV.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.