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Article

Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas.

International journal of oncology - 1 Oct 2005

Tokumoto Noriaki, Ikeda Satoshi, Ishizaki Yasuyo, Kurihara Takeshi, Ozaki Shinji, Iseki Masahiko, Shimizu Yosuke, Itamoto Toshiyuki, Arihiro Koji, Okajima Masazumi, Asahara Toshimasa

Abstract excerpt

The mechanisms of carcinogenesis in intrahepatic cholangiocarcinoma (ICC) are not well characterized although alterations in several oncogenes and onco-suppressor genes have been reported to occur in ICC. In the present study, we focused on alterations in the Wnt signaling components and target genes by analyzing 24 surgically resected samples of ICC. Immunohistochemical analysis of beta-catenin showed positive...

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PMID: 16142313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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