Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Effects of Culture Conditions on CYP3A4 and MDR1 mRNA Induction by 1α,25-Dihydroxyvitamin D3 in Human Intestinal Cell Lines, Caco-2 and LS180†

1 Jan 2005

Abstract excerpt

To evaluate an in vitro model suitable for investigating intestinal first-pass drug metabolism, CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) (VD3) was examined in two human intestinal cell lines, Caco-2 and LS180, under various culture conditions. CYP3A4 mRNA expression was induced by 100 nM VD3 at levels between 234-549 times above normal in Caco-2 cells for 2 weeks and by 74-200 times above...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Pharmacogenetics and Drug Metabolism
Share to Vitamin D Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16141606
DOI: 10.2133/dmpk.20.268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Effects of Culture Conditions on CYP3A4 and MDR1 mRNA Induction by 1α,25-Dihydroxyvitamin D3 in Human Intestinal Cell Lines, Caco-2 and LS180†PMID 16141606Read ↗

Validation of an MPS based intestinal cell culture model for the evaluation of drug-induced toxicitySemantic proximity Read ↗

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell linesSemantic proximity Read ↗

Are MDCK Cells Transfected with the Human MDR1 Gene a Good Model of the Human Intestinal Mucosa?Semantic proximity Read ↗

Drug-Permeability and Transporter Assays in Caco-2 and Mdck Cell LinesSemantic proximity Read ↗

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 ModelSemantic proximity Read ↗

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cellsSemantic proximity Read ↗

Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.Semantic proximity Read ↗

Regulation of cytochrome P450IA1 gene expression in a human intestinal cell line, Caco-2.Semantic proximity Read ↗

The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristicsSemantic proximity Read ↗

Caco-2/TC7 cell line characterization for intestinal absorption: How reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?Semantic proximity Read ↗

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by RifampinSemantic proximity Read ↗

The 3-epi- and 24-oxo-derivatives of 1alpha,25 dihydroxyvitamin D(3) stimulate transcription through the vitamin D receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.