Article
Interference with the Microenvironmental Support Impairs the <i>De novo</i> Formation of Bone Metastases <i>In vivo</i>
1 Sept 2005
Abstract excerpt
Interference with the microenvironmental growth support is an attractive therapeutic strategy for repressing metastatic tumor growth. Bone is a highly dynamic tissue that is continuously remodeled by bone resorption and subsequent bone formation. Growth factors supporting bone metastatic growth are released especially during bone resorption. Differently from most other tissues, drugs that can limit local...
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