Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures.

Abstract excerpt

There is an increased interest in utilizing mechanistic data in support of the cancer risk assessment process for ionizing radiation and environmental chemical exposures. In this regard, the use of biologically based dose-response models is particularly advocated. The aim is to provide an enhanced basis for describing the nature of the dose-response curve for induced tumors at low levels of exposure. Cellular...

Topics

• Adaptation, Physiological
• Bystander Effect
• Chromosome Aberrations
• Dose-Response Relationship, Radiation
• Genomic Instability
• Humans
• Mutation
• Radiation, Ionizing
• Risk Assessment