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Article

EPAS1/HIF-2α is a driver of mammalian pexophagy

22 May 2015

Abstract excerpt

Oxygen (O2) is an essential substrate in cellular metabolism and signaling and as such is linked to the survival and normal function of metazoans. Central to the molecular mechanisms underlying O2 homeostasis are hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of O2-regulated α subunits (HIF1A/HIF-1α or EPAS1/HIF-2α), and a constitutively expressed ARNT/HIF-1β subunit, that serve as...

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PMID: 25997392
DOI: 10.1080/15548627.2015.1045180

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