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Article

Determinants of amentoflavone interaction at the GABA(A) receptor.

European journal of pharmacology - 20 Sept 2005

Hansen Reena S, Paulsen Isabelle, Davies Martin

Abstract excerpt

We investigated the recognition properties of different GABA(A) receptor subtypes and mutant receptors for the biflavonoid amentoflavone, a constituent of St. John's Wort. Radioligand binding studies showed that amentoflavone recognition paralleled that of the classical benzodiazepine diazepam in that it had little or no affinity for alpha4- or alpha6-containing receptors. Lysine and alanine substitutions at...

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Source

Identifiers

PMID: 16129428
DOI: 10.1016/j.ejphar.2005.06.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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