Article
Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism.
The FEBS journal - 1 Sept 2005
Gomes Ricardo A, Sousa Silva Marta, Vicente Miranda Hugo, Ferreira António E N, Cordeiro Carlos A A, Freire Ana Ponces
Abstract excerpt
Methylglyoxal is the most important intracellular glycation agent, formed nonenzymatically from triose phosphates during glycolysis in eukaryotic cells. Methylglyoxal-derived advanced glycation end-products are involved in neurodegenerative disorders (Alzheimer's, Parkinson's and familial amyloidotic polyneurophathy) and in the clinical complications of diabetes. Research models for investigating protein...
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