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Article

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

Molecular and cellular biology - 1 Nov 2004

Martinu Lenka, Masuda-Robens Jeffrey M, Robertson Sarah E, Santy Lorraine C, Casanova James E, Chou Margaret M

Abstract excerpt

TBC (Tre-2/Bub2/Cdc16) domains are predicted to encode GTPase-activating proteins (GAPs) for Rab family G proteins. While approximately 50 TBC proteins are predicted to exist in humans, little is known about their substrate specificity. Here we show that TRE17 (also called Tre-2 and USP6), a founding member of the TBC family, targets the Arf family GTPase Arf6, which regulates plasma membrane-endosome...

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Identifiers

PMID: 15509780
DOI: 10.1128/MCB.24.22.9752-9762.2004
PMCID: PMC525471

Genes

USP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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