Article
Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles.
Molecular and cellular biology - 1 Apr 2004
Chatel-Chaix Laurent, Clément Jean-Francois, Martel Catherine, Bériault Véronique, Gatignol Anne, DesGroseillers Luc, Mouland Andrew J
Abstract excerpt
Staufen is a host protein that is selectively incorporated into human immunodeficiency virus type 1 (HIV-1) particles in a poorly defined process that involves the selection of HIV-1 genomic RNA for encapsidation and the activity of its third double-stranded RNA-binding domain (dsRBD3). To better understand this, we characterized its interactions with pr55(Gag), the principal mediator of HIV-1 genomic RNA...
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