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Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma

1 Oct 1995

Abstract excerpt

Mantle cell lymphoma (MCL) is a clinicopathologic entity that is difficult to diagnose on histopathologic criteria. Approximately 50% to 70% of MCL contain a t(11;14)(q13;q32) translocation involving the cyclin D1 gene. Irrespective of this rearrangement, almost all MCL show overexpression of the cyclin D1 gene at the mRNA level. Other B-cell non-Hodgkin's lymphomas (NHL) do not show this rearrangement or...

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Identifiers

PMID: 7670110
DOI: 10.1182/blood.v86.7.2715.2715

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