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Article

Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.

Neuron - 25 Oct 2001

Clandinin T R, Lee C H, Herman T, Lee R C, Yang A Y, Ovasapyan S, Zipursky S L

Abstract excerpt

Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye connect to specific targets in the optic lobe. Using a behavioral screen, we identified LAR, a receptor tyrosine phosphatase, as being required for R cell target specificity. In LAR mutant mosaic eyes, R1-R6 cells target to the lamina correctly, but fail to choose the correct pattern of target neurons. Although mutant R7 axons...

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Source

Identifiers

PMID: 11683994
DOI: 10.1016/s0896-6273(01)00474-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system.PMID 11683994Read ↗

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Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents.Semantic proximity Read ↗

Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting.Semantic proximity Read ↗

The receptor tyrosine kinase Off-track is required for layer-specific neuronal connectivity in Drosophila.Semantic proximity Read ↗

Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in <i>Drosophila</i>Semantic proximity Read ↗

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mip causes hyperinnervation of a retinotopic map in Drosophila by excessive recruitment of R7 photoreceptor cells.Semantic proximity Read ↗

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