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Article

Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues

25 Aug 2005

Abstract excerpt

BACKGROUND: Divalent metal transporter 1 (DMT1) is a transmembrane glycoprotein which mediates the proton-coupled transport of a variety of divalent metal ions. Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3' untranslated region, are implicated in apical iron transport and endosomal iron transport respectively. Although the expression...

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PMID: 16123094
DOI: 10.1093/humrep/dei246

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