Article
Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI.
Epilepsy research - 1 Aug 2010
Wagner Amy K, Miller Megan A, Scanlon Joelle, Ren Dianxu, Kochanek Patrick M, Conley Yvette P
Abstract excerpt
Post-traumatic seizures (PTS) are a significant complication from traumatic brain injury (TBI). Adenosine, a major neuroprotective and neuroinhibitory molecule, is important in experimental epilepsy models. Thus, we investigated the adenosine A1 receptor (A1AR) gene and linked it with clinical data extracted for 206 subjects with severe TBI. Tagging SNPs rs3766553, rs903361, rs10920573, rs6701725, and rs17511192...