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Article

A kinesin switch I arginine to lysine mutation rescues microtubule function.

The Journal of biological chemistry - 3 Oct 2003

Klumpp Lisa M, Mackey Andrew T, Farrell Christopher M, Rosenberg John M, Gilbert Susan P

Abstract excerpt

Switch I and II are key active site structural elements of kinesins, myosins, and G-proteins. Our analysis of a switch I mutant (R210A) in Drosophila melanogaster kinesin showed a reduction in microtubule affinity, a loss in cooperativity between the motor domains, and an ATP hydrolysis defect le...

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Identifiers

PMID: 12860992
DOI: 10.1074/jbc.M304250200
PMCID: PMC2265777

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12860992-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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