Article
A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans.
Genetics - 1 Dec 2005
Favorov Alexander V, Andreewski Timophey V, Sudomoina Marina A, Favorova Olga O, Parmigiani Giovanni, Ochs Michael F
Abstract excerpt
In recent years, the number of studies focusing on the genetic basis of common disorders with a complex mode of inheritance, in which multiple genes of small effect are involved, has been steadily increasing. An improved methodology to identify the cumulative contribution of several polymorphous genes would accelerate our understanding of their importance in disease susceptibility and our ability to develop new...
Topics
- Algorithms
- Alleles
- Bayes Theorem
- Computer Simulation
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Inheritance Patterns
- Markov Chains
- Models, Genetic
- Monte Carlo Method
- Multiple Sclerosis