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Article

A Markov chain Monte Carlo technique for identification of combinations of allelic variants underlying complex diseases in humans.

Genetics - 1 Dec 2005

Favorov Alexander V, Andreewski Timophey V, Sudomoina Marina A, Favorova Olga O, Parmigiani Giovanni, Ochs Michael F

Abstract excerpt

In recent years, the number of studies focusing on the genetic basis of common disorders with a complex mode of inheritance, in which multiple genes of small effect are involved, has been steadily increasing. An improved methodology to identify the cumulative contribution of several polymorphous genes would accelerate our understanding of their importance in disease susceptibility and our ability to develop new...

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Identifiers

PMID: 16118183
DOI: 10.1534/genetics.105.048090
PMCID: PMC1456130

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