Article
Monte Carlo likelihood in the genetic mapping of complex traits.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jun 1994
Thompson E A
Abstract excerpt
Many of the likelihoods arising in the analysis of complex genetic traits, particularly in linkage analysis, are computationally infeasible. Where exact likelihoods cannot be computed, Monte Carlo estimates of likelihoods may provide a satisfactory alternative. Although simulation on pedigrees is straightforward, simulation conditional upon observed phenotypic data is not. However, recent advances in Markov chain...
Topics
- Algorithms
- Chromosome Mapping
- Genetic Linkage
- Genotype
- Humans
- Models, Genetic
- Models, Statistical
- Monte Carlo Method
- Pedigree
- Probability