Article
Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women.
Chinese medical journal - 20 Jul 2005
Su Shao-yong, Chen Jian-hong, Huang Jian-feng, Wang Xiao-ling, Zhao Jian-gong, Shen Yan, Qiang Bo-qin, Gu Dong-feng
Abstract excerpt
BACKGROUND: The oxidative modification of low-density lipoprotein in the artery wall is currently believed to be central to the pathogenesis of atherosclerosis. Paraoxonase (PON1), an enzyme located on high-density lipoprotein (HDL), can prevent low-density lipoprotein (LDL) from oxidation at a certain extent. Recent studies show two other members of paraoxonase gene family, PON2 and PON3, possess antioxidant...
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