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Article

Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.

Molecular biology reports - 1 Sept 2012

Lin Hsiu-Ling, Ueng Kwo-Chang, Hsieh Yih-Shou, Chiang Whei-Ling, Yang Shun-Fa, Chu Shu-Chen

Abstract excerpt

Coronary artery disease (CAD) was the second leading cause of death during the last 3 years in Taiwan. Smooth muscle cells, monocytes/macrophages, and endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within atherosclerotic plaques following binding to the chemokine receptor-2 (CCR-2). Previous studies have well-documented the association between MCP-1 expression and susceptibility to, or...

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Identifiers

PMID: 22752804
DOI: 10.1007/s11033-012-1773-y

Genes

CAD
CCR2

Variants

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