Article
Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype.
Thrombosis and haemostasis - 1 Aug 2005
Gnatenko Dmitri V, Cupit Lisa D, Huang Emily C, Dhundale Anilkumar, Perrotta Peter L, Bahou Wadie F
Abstract excerpt
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quantitative and qualitative platelet defects associated with cardiovascular and thrombohemorrhagic symptoms, not...
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