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Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression

7 Nov 2022

Abstract excerpt

Thromboses are major causes of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET) diseases associated with JAK2V617F mutation. However, the molecular mechanism(s) of increased thrombosis in PV and ET remain unknown. Kruppel-like factor 2 (KLF2) is a transcription factor that regulates expression of genes associated with inflammation and thrombosis; the absence of KLF2 in...

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PMID: 36343116
DOI: 10.1182/bloodadvances.2022008052

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