Article
Screening for familial ovarian cancer: failure of current protocols to detect ovarian cancer at an early stage according to the international Federation of gynecology and obstetrics system.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2005
Stirling Diane, Evans D Gareth R, Pichert Gabriella, Shenton Andrew, Kirk Elaine N, Rimmer Sylvia, Steel C Michael, Lawson Sheila, Busby-Earle R M Camille, Walker Jane, Lalloo Fiona I, Eccles Diana M, Lucassen Anneke M, Porteous Mary E
Abstract excerpt
PURPOSE: To assess the effectiveness of annual ovarian cancer screening (transvaginal ultrasound and serum CA-125 estimation) in detecting presymptomatic ovarian cancer in women at increased genetic risk. PATIENTS AND METHODS: A cohort of 1,110 women at increased risk of ovarian cancer were screened between January 1991 and March 2004; 553 were moderate-risk individuals (4% to 10% lifetime risk) and 557 were...
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